The Prion Disease Database (PDDB) is a public database that supports the prion disease research community by collecting, integrating, and presenting data from public sources and collaborating laboratories. The PDDB was originally created by the Institute for Systems Biology and the McLaughlin Research Institute, which have research prion disease using a systems biology approach. The PDDB is located at http://prion.systemsbiology.net.
The PDDB contains time-course mRNA measurements spanning the interval from prion inoculation through appearance of clinical signs in eight mouse strain-prion strain combinations and histoblots showing temporal PrPSc accumulation patterns in brains from each mouse–prion combination. To facilitate prion research, the PDDB also provides a suite of analytical tools for reconstructing dynamic networks via integration of temporal mRNA and interaction data and for analyzing these networks to generate hypotheses.
N Gehlenborg*, D Hwang*, IY Lee*, H Yoo, B Petritis, D Baxter, R Pitstick, B Marzolf, SJ DeArmond, GA Carlson and LE Hood, “The Prion Disease Database: A Comprehensive Transcriptome Resource for Systems Biology Research in Prion Diseases“, Database 2009:bap011 (2009).
D Hwang*, IY Lee*, H Yoo*, N Gehlenborg, J Cho, B Petritis, D Baxter, R Pitstick, R Young, D Spicer, N Price, JG Hohmann, SJ DeArmond, GA Carlson and LE Hood, “A Systems Approach to Prion Disease“, Molecular Systems Biology 5:252 (2009).